Infinite‐dilution viscoelastic properties of fibrinogen and intermediate fibrin polymer
Identifieur interne : 005057 ( Main/Exploration ); précédent : 005056; suivant : 005058Infinite‐dilution viscoelastic properties of fibrinogen and intermediate fibrin polymer
Auteurs : Norio Nemoto [États-Unis, Japon] ; F. Henry M. Nestler [États-Unis] ; John L. Schrag [États-Unis] ; John D. Ferry [États-Unis]Source :
- Biopolymers [ 0006-3525 ] ; 1977-09.
English descriptors
- Teeft :
- Abscissa axis, Aqueous fibrinogen solution, Aqueous glycerol, Bovine fibrinogen, Central nodule, Chem, Concentration range, Dimensionless frequency, Elastic spheres, Electrical birefringence, Ellipsoid, Equal volume, Fibrin, Fibrin monomer, Fibrinogen, Finite concentration, Flow birefringence, Frequency dependence, Frequency dependencies, Frequency range, Glycerol, Good agreement, Hexamethylene glycol, Hydrodynamic, Hydrodynamic interaction, Infinite dilution, Intermediate fibrin polymer, Intermediate polymer, Intrinsic viscosity, Ionic strength, Jointed, Jointed trinodular, Logarithmic plots, Longest relaxation time, Loss shear moduli, Modulus, Molecular dimensions, Molecular theory, Molecular weight, Monomer, Monomer length, Native fibrinogen, Negligible hydrodynamic interaction, Nemoto, Nodule, Nodule radius, Ordinate axis, Oscillatory flow birefringence, Parallel chains, Phys, Polymer, Prolate ellipsoid, Relaxation time, Relaxation times, Resonator, Resonator apparatus, Rigid trinodular, Schrag, Sedimentation coefficients, Small amounts, Solvent viscosity, Theoretical curves, Titanium alloy, Tobacco mosaic, Trinodular, Trinodular rods, Viscoelastic behavior, Viscoelastic measurements, Viscoelastic properties.
Abstract
The storage and loss shear moduli, G′ and G″, have been measured for dilute solutions of bovine fibrinogen in 68% aqueous glycerol and of intermediate fibrin polymer in 6M hexamethylene glycol, by the Birnboim‐Schrag multiple‐lumped resonator apparatus with titanium alloy resonators. The frequency range was 100–5800 Hz, the concentration range 1–6 g/l., and the temperatures 10.0 and 25.0°C. The shear moduli G′ and G″ at finite concentration, and the extrapolated instrinsic shear moduli [G′] and [G″], as functions of frequency, were compared with the predictions of various molecular theories. For fibrinogen, the frequency dependence agreed quite well with the calculations of Hassager for a trinodular rod as modified for the presence of small amounts of dimeric and trimeric aggregates which were deduced from parallel measurements of oscillatory flow birefringence. It was not possible, however, to distinguish between a linearly rigid configuration and one which is freely jointed at the central nodule. A model of a soft elastic sphere (simulating the cage model of Köppel) appeared to be very unlikely. The relaxation time for a rigid trinodular rod and the longest relaxation time for a jointed trinodular rod, calculated from molecular dimensions on the basis of electron microscope measurements, are somewhat smaller than the corresponding observed values; the discrepancy suggests that the molecule is swollen in solution. For the intermediate polymer (which was formed under conditions where ligation is expected), the frequency dependence agreed quite well with that predicted either for a prolate ellipsoid (Cerf‐Scheraga‐Saitō) or for a cylindrical rod (Yamakawa). The relaxation time obtained by fitting to theory agrees quite well with that calculated for a cylindrical rod with molecular dimensions based on a degree of polymerization of 20 and lateral binary association with staggered overlapping.
Url:
DOI: 10.1002/bip.1977.360160910
Affiliations:
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Ferry</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:028A38BF87B82FDC10B860E0611C15CC209202BC</idno><date when="1977" year="1977">1977</date><idno type="doi">10.1002/bip.1977.360160910</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-FSD778GF-B/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001452</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001452</idno><idno type="wicri:Area/Istex/Curation">001452</idno><idno type="wicri:Area/Istex/Checkpoint">002505</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002505</idno><idno type="wicri:doubleKey">0006-3525:1977:Nemoto N:infinite:dilution:viscoelastic</idno><idno type="wicri:Area/Main/Merge">005137</idno><idno type="wicri:Area/Main/Curation">005057</idno><idno type="wicri:Area/Main/Exploration">005057</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Infinite‐dilution viscoelastic properties of fibrinogen and intermediate fibrin polymer</title><author><name sortKey="Nemoto, Norio" sort="Nemoto, Norio" uniqKey="Nemoto N" first="Norio" last="Nemoto">Norio Nemoto</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Chemistry, University of Wisconsin, Madison</wicri:cityArea></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Current Address: Institute of Chemical Research, Kyoto University, Uji, Kyoto‐fu 611</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author><author><name sortKey="Nestler, F Henry M" sort="Nestler, F Henry M" uniqKey="Nestler F" first="F. Henry M." last="Nestler">F. Henry M. Nestler</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Chemistry, University of Wisconsin, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Schrag, John L" sort="Schrag, John L" uniqKey="Schrag J" first="John L." last="Schrag">John L. Schrag</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Chemistry, University of Wisconsin, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Ferry, John D" sort="Ferry, John D" uniqKey="Ferry J" first="John D." last="Ferry">John D. Ferry</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Chemistry, University of Wisconsin, Madison</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Biopolymers</title><title level="j" type="alt">BIOPOLYMERS</title><idno type="ISSN">0006-3525</idno><idno type="eISSN">1097-0282</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1957">1957</biblScope><biblScope unit="page" to="1969">1969</biblScope><biblScope unit="page-count">13</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1977-09">1977-09</date></imprint><idno type="ISSN">0006-3525</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-3525</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abscissa axis</term><term>Aqueous fibrinogen solution</term><term>Aqueous glycerol</term><term>Bovine fibrinogen</term><term>Central nodule</term><term>Chem</term><term>Concentration range</term><term>Dimensionless frequency</term><term>Elastic spheres</term><term>Electrical birefringence</term><term>Ellipsoid</term><term>Equal volume</term><term>Fibrin</term><term>Fibrin monomer</term><term>Fibrinogen</term><term>Finite concentration</term><term>Flow birefringence</term><term>Frequency dependence</term><term>Frequency dependencies</term><term>Frequency range</term><term>Glycerol</term><term>Good agreement</term><term>Hexamethylene glycol</term><term>Hydrodynamic</term><term>Hydrodynamic interaction</term><term>Infinite dilution</term><term>Intermediate fibrin polymer</term><term>Intermediate polymer</term><term>Intrinsic viscosity</term><term>Ionic strength</term><term>Jointed</term><term>Jointed trinodular</term><term>Logarithmic plots</term><term>Longest relaxation time</term><term>Loss shear moduli</term><term>Modulus</term><term>Molecular dimensions</term><term>Molecular theory</term><term>Molecular weight</term><term>Monomer</term><term>Monomer length</term><term>Native fibrinogen</term><term>Negligible hydrodynamic interaction</term><term>Nemoto</term><term>Nodule</term><term>Nodule radius</term><term>Ordinate axis</term><term>Oscillatory flow birefringence</term><term>Parallel chains</term><term>Phys</term><term>Polymer</term><term>Prolate ellipsoid</term><term>Relaxation time</term><term>Relaxation times</term><term>Resonator</term><term>Resonator apparatus</term><term>Rigid trinodular</term><term>Schrag</term><term>Sedimentation coefficients</term><term>Small amounts</term><term>Solvent viscosity</term><term>Theoretical curves</term><term>Titanium alloy</term><term>Tobacco mosaic</term><term>Trinodular</term><term>Trinodular rods</term><term>Viscoelastic behavior</term><term>Viscoelastic measurements</term><term>Viscoelastic properties</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="de">The storage and loss shear moduli, G′ and G″, have been measured for dilute solutions of bovine fibrinogen in 68% aqueous glycerol and of intermediate fibrin polymer in 6M hexamethylene glycol, by the Birnboim‐Schrag multiple‐lumped resonator apparatus with titanium alloy resonators. The frequency range was 100–5800 Hz, the concentration range 1–6 g/l., and the temperatures 10.0 and 25.0°C. The shear moduli G′ and G″ at finite concentration, and the extrapolated instrinsic shear moduli [G′] and [G″], as functions of frequency, were compared with the predictions of various molecular theories. For fibrinogen, the frequency dependence agreed quite well with the calculations of Hassager for a trinodular rod as modified for the presence of small amounts of dimeric and trimeric aggregates which were deduced from parallel measurements of oscillatory flow birefringence. It was not possible, however, to distinguish between a linearly rigid configuration and one which is freely jointed at the central nodule. A model of a soft elastic sphere (simulating the cage model of Köppel) appeared to be very unlikely. The relaxation time for a rigid trinodular rod and the longest relaxation time for a jointed trinodular rod, calculated from molecular dimensions on the basis of electron microscope measurements, are somewhat smaller than the corresponding observed values; the discrepancy suggests that the molecule is swollen in solution. For the intermediate polymer (which was formed under conditions where ligation is expected), the frequency dependence agreed quite well with that predicted either for a prolate ellipsoid (Cerf‐Scheraga‐Saitō) or for a cylindrical rod (Yamakawa). The relaxation time obtained by fitting to theory agrees quite well with that calculated for a cylindrical rod with molecular dimensions based on a degree of polymerization of 20 and lateral binary association with staggered overlapping.</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Région du Kansai</li><li>Wisconsin</li></region><settlement><li>Kyoto</li></settlement><orgName><li>Université de Kyoto</li></orgName></list><tree><country name="États-Unis"><region name="Wisconsin"><name sortKey="Nemoto, Norio" sort="Nemoto, Norio" uniqKey="Nemoto N" first="Norio" last="Nemoto">Norio Nemoto</name></region><name sortKey="Ferry, John D" sort="Ferry, John D" uniqKey="Ferry J" first="John D." last="Ferry">John D. Ferry</name><name sortKey="Nestler, F Henry M" sort="Nestler, F Henry M" uniqKey="Nestler F" first="F. Henry M." last="Nestler">F. Henry M. Nestler</name><name sortKey="Schrag, John L" sort="Schrag, John L" uniqKey="Schrag J" first="John L." last="Schrag">John L. Schrag</name></country><country name="Japon"><region name="Région du Kansai"><name sortKey="Nemoto, Norio" sort="Nemoto, Norio" uniqKey="Nemoto N" first="Norio" last="Nemoto">Norio Nemoto</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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